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KMID : 0921620140440010095
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Journal of Bacteriology and Virology
2014 Volume.44 No. 1 p.95 ~ p.101
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Anti-inflammatory Effect of Plocamium telfairiae Extract in LPS-stimulated Bone Marrow-derived Macrophages and Dendritic Cells
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Shrestha Eileen
Kim So-Hyun
Chae Doo-Byeong
Manzoor Zahid
Kang Hee-Kyoung
Hyun Jin-Won
Ko Mi-Hee
Koh Young-Sang
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Abstract
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Marine algae are rich sources of various biologically active compounds with potential pharmaceutical properties. In the present study, we investigated the inhibitory effects of Plocamium telfairiae extract (PTE) on proinflammatory cytokine production in bone marrow-derived macrophage (BMDMs) and dendritic cells (BMDCs). PTE pre-treatment in LPS-stimulated BMDMs and BMDCs showed a strong inhibition on interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α production as compared to non-treated controls. PTE pre-treatment showed significant inhibition on phosphorylation of mitogen-activated protein kinases and degradation of inhibitor of kappa B (IκBα). Taken together, these results suggest that PTE may have potential anti-inflammatory property and hence, warrant further studies concerning the potentials of PTE for medicinal purpose.
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KEYWORD
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Plocamium telfairiae, Interleukin, Proinflammatory cytokine, Inflammation
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